Background: Osteosarcopenia is a geriatric syndrome that is associated with an increased risk of falls, fragility fractures, and mortality. Resistance exercise and nutritional support with protein and nutritional supplementation effectively mitigate progression of osteosarcopenia. We evaluated the efficacy of a 6-month progressive resistance exercise program in postmenopausal women with osteosarcopenia.

Methods: This assessor-blinded randomised controlled trial comprised 34 postmenopausal women with osteosarcopenia who were assigned to either a resistance exercise group (RE; n=17) or a home exercise group (HE, n=17). Both groups received home exercise brochures and nutritional supplementation (40 g protein, 600 mg calcium, and 1600 IU vitamin D). The RE group additionally attended semi-weekly supervised resistance training sessions. The primary outcome was the change in the skeletal muscle index (SMI). The secondary outcomes included changes in hand-grip strength (HGS) and physical performance.

Results: 17 and 16 participants from the RE and HE groups, respectively, completed the intervention. The RE group showed significantly greater SMI improvement at 12 weeks (0.310 ± 0.343 kg/m² vs. 0.011 ± 0.423 kg/m² in HE).However, SMI improvement between RE group and HE group were not significant different at 24weeks (RE group; 0.121 ± 0.316 kg/m² , HE group; -0.024 ± 0.258 kg/m²).Though HGS and physical performance improved significantly in both groups, the RE group showed superior HGS gains at 6 and 18 weeks.

Conclusions: A 6-month program of progressive resistance exercise combined with nutritional support improved muscle mass and strength in postmenopausal women with osteosarcopenia. Home exercises with nutrition alone also enhanced physical performance.

Authors:
Changwon Moon, Chungnam National University Hospital of Korea, South Korea
Ju Hyun Lee, Chungnam National University Hospital, South Korea
Seong Eun Heo, Chungnam National University Hospital, South Korea
Seul Lee, Chungnam National University Hospital, South Korea
Su Bin Nam, Chungnam National University Hospital, South Korea
Bo Mi Choi, Chungnam National University Sejong Hospital, South Korea

About the Presenter(s)
Dr. Changwon Moon is an assistant professor at the Chungnam National University Hospital of Korea, Recently, he has been focusing on research of sarcopenia, is preparing a paper on the effects of nutritional and exercise interventions for sarcopenia

See this presentation on the full schedule – Friday Schedule

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